【摘要】 目的:了解门诊甲真菌病患者致病性真菌的菌种分布特征,以及对常用抗真菌药物的耐药情况。方法:收集我院皮肤科门诊2010年1月至2011年12月甲真菌病患者的病甲标本做真菌培养,对培养结果阳性者用ID真菌鉴定板条进行鉴定分型,纸片扩散法进行药敏试验。结果:真菌培养鉴定的363例患者标本中,266份培养出阳性菌株,总阳性率为73.3%,皮肤癣菌244株(占67.2%),霉菌39株(占10.8%),酵母菌77株(占21.1%);真菌耐药率分别为5-氟胞嘧啶25.5%、氟康唑11.9%、酮康唑6.7%、伊曲康唑2.1%、两性霉素B 0%,药物敏感率分别为5-氟胞嘧啶70.4%、氟康唑81.3%、酮康唑87.7%、伊曲康唑95.2%、两性霉素B 99.1%。结论:甲真菌病患者致病性真菌以皮肤癣菌最为常见,菌株对两性霉素B和伊曲康唑较为敏感。更多还原

【Abstract】 Objective: To investigate the distribution of pathogenic fungi species and its drug resistance in the clinical onychomycosis.Methods: The cases of onychomycosis were randomly selected in our hosptital from january 2010 to december 2011.The fungal cultures were performed on the lesions.ID identification strip was employed to identify the fungi and drug sensitive test was performed by disk diffusion test in the culture positive cases.Results: Among 363 suspected cases,266(73.3%) cases were cultured with positive result,including dermatophytes 244(67.2%),yeasts 39(10.8%),microzymes 77(21.1%).Of all the drug resistance,there were 5fluorocytosine(25.5%),fluconazole(111.9%),ketoconazole(6.7%),itracorarole(2.1%),amphotericin B(0%).The isolated fungi were sensitive to 5-fluorocytosine(70.4%),fluconazole(81.3%),ketoconazole(87.7%),itracorarole(95.2%),amphotericin B(99.1%).Conclusion: The main clinical type of onychomycosis was dermatophytes.The fungi were relatively sensitive to tracorarole and amphotericinB.更多还原