【摘要】 目的:观察他汀类药物对动脉粥样硬化(AS)的疗效。方法:选取温州医学院附属第一医院神经内一科2010年11月-2011年6月脑梗死住院患者中经颈动脉B超证实有AS者130例,给予阿托伐他汀20 mg/d或瑞舒伐他汀10 mg/d,比较用药前和用药后12个月末总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、血浆高敏C反应蛋白(hs-CRP)、最大平均颈动脉内膜-中层厚度(CIMT)的变化情况。结果:与用药前相比,TC下降24%(P<0.05),TG下降19%(P<0.05),LDL-C下降36%(P<0.05),但没有显著升高高密度脂蛋白(HDL-C),治疗前后hs-CRP差异有统计学意义,最大平均CIMT治疗前后相比(1.99比1.92 mm,P<0.05)差异有统计学意义。结论:在脑梗死患者中两种他汀类药物可显著降低TC、TG、LDL-C水平,其中LDL-C水平下降最显著,且有可逆转CIMT的作用。更多还原

【Abstract】 Objective: To evaluate the effects of atorvastatin and rosuvastatin on the carotid atherosclerosis in patients with cerebral infarction.Methods: Doppler ultrasonog-raphy of carotid artery amongst patients with cerebral infarction was performed in hospital.There were a total of 130 patients with atherosclerosis in carotid artery.Some taken atorvastatin 20 mg daily,the other taken rosuvastatin 10 mg daily.Results: After 12 months of administration,the statins treatment was associated with 36% reduction in LDL-C,24% reduction in total cholesterol,and 19% reduction in triglycerides(all P<0.05 compared with them than before treatment).The difference of mean maximum CIMT progression between before and after the treatment was statistically significant after 12 months(1.99 vs 1.92 mm P<0.05).Conclusion: Statins have good lipid-lowering effects on patients with cerebral infarction and result in significant regression of carotid atherosclerosis.更多还原