【摘要】 【目的】探讨血尿酸水平与急性缺血性脑卒中及动脉粥样斑块的相关性。【方法】将417例急性缺血性脑卒中患者纳入病例组,212例体检者纳入对照组,分别对病例组和对照组基线资料进行比较,并分析病例组各TOAST(trial of org 10172 inacute stroke treatment)亚型与对照组血尿酸水平的关系以及血尿酸与血脂的关系。根据颈部血管彩超结果将缺血性脑卒中患者分为有斑块组和无斑块组,比较两组血尿酸的差异。【结果】大动脉粥样硬化型缺血性脑卒中组与对照组血尿酸水平相比明显升高,差异有统计学意义(P<0.01)。颈动脉有斑块缺血性脑卒中组较颈动脉无斑块缺血性脑卒中组血尿酸水平显著升高,差异有统计学意义(P<0.01)。缺血性脑卒中合并高尿酸血症者较血尿酸正常者甘油三酯升高、高密度脂蛋白降低,差异有统计学意义(P<0.05)。【结论】高尿酸可促进动脉硬化的发生,与急性缺血性脑卒中的发生、发展密切相关,可能是急性缺血性脑卒中的一项独立危险因素。更多还原

【Abstract】 【Objective】To investigate the correlation of the level of serum uric acid in patients with acute ischemic stroke and atherosclerotic plaque.【Methods】417 patients with acute ischemic stroke were enrolled in cases group,and 212 healthy people as a control group.The baseline data of the case group and the control group were compared.The case group was divided into five subgroups according to the TOAST classification,then the serum uric acid were compared,and analyze the relationship between serum uric acid and blood lipids.417 acute ischemic stroke patients were divided into plaque and no plaque group by cervical vascular color ultrasonic inspection,and the differences of serum uric acid of the two groups were compared.【Results】The level of serum uric acid in large artery atherosclerosis ischemic stroke group obviously higher than control group,and the difference was statistically significant(P < 0.01).Serum uric acid level in plaque group was significantly increased as compared with no plaque group,and the difference was statistically significant(P < 0.01).Triglyceride was higher in patients with ischemic stroke complicating hyperuricemia than those whose serum uric acid were normal,but high-density lipoprotein has opposite result between the two groups,the differences was statistically significant(P < 0.05).【Conclusions】High serum uric acid may promote the occurrence of atherosclerosis and it is closely related with the occurrence and development of acute ischemic stroke.High serum uric acid may be an independent risk factor of acute ischemic stroke.更多还原