Single-Step Fabrication of Gd₂O₃@SiO₂ Nanoparticles for use as MRI Contrast Agents by Pulsed Laser Ablation in Liquid

【摘要】 Gd₂O₃@SiO₂ nanoparticles with a core-shell structure are synthesized by pulsed laser ablation in liquid（PLAL） in single steps.A Gd₂O₃ target immersed in tetraethyl orthosilicate（TEOS） is ablated by a microsecond Nd:YAG laser,which induces the generation of a Gd₂O₃ plasma plume and pyrolysis of the TEOS.We propose that the moment Gd₂O₃ nanoparticles are formed they will be coated immediately by SiO₂ and directly synthesized Gd₂O₃@SiO₂ core-shell nanoparticles.These particles obtain high 7*1 relaxivity of 5.26s^-1mM^-1 and are used as Ti-weighted magnetic resonance imaging contrast agents.It is shown that the PLAL technique is promising for fabricating core-shell structure nanomaterial with potential medical applications.更多还原

【Abstract】 Gd₂O₃@SiO₂ nanoparticles with a core-shell structure are synthesized by pulsed laser ablation in liquid（PLAL） in single steps.A Gd₂O₃ target immersed in tetraethyl orthosilicate（TEOS） is ablated by a microsecond Nd:YAG laser,which induces the generation of a Gd₂O₃ plasma plume and pyrolysis of the TEOS.We propose that the moment Gd₂O₃ nanoparticles are formed they will be coated immediately by SiO₂ and directly synthesized Gd₂O₃@SiO₂ core-shell nanoparticles.These particles obtain high 7*1 relaxivity of 5.26s^-1mM^-1 and are used as Ti-weighted magnetic resonance imaging contrast agents.It is shown that the PLAL technique is promising for fabricating core-shell structure nanomaterial with potential medical applications.更多还原