【摘要】 背景:炎症性肠病(IBD)是一种病因未明且反复发作的慢性炎性肠道疾病,包括克罗恩病(CD)和溃疡性结肠炎(UC)。近年我国IBD的发病率呈逐年上升趋势。目的:回顾性分析IBD患者的人口资料。方法:回顾性分析2002年7月～2011年6月上海瑞金医院766例IBD住院患者的性别、年龄、居住地、家族聚集性等人口资料。结果:IBD的发病率呈逐年上升趋势。CD和UC患者的男女比分别为2.02∶1和1.36∶1。CD患者确诊时的平均年龄明显低于UC患者[(33.30±14.76)岁对(40.10±17.55)岁,P<0.0001]。CD患者发病高峰年龄较UC早。IBD城市患者多于农村患者。1.14%的CD患者和1.68%的UC患者存在家族史。结论:2002～2011年间IBD的新发例数呈明显上升趋势,且CD发病率的增幅明显大于UC;CD和UC患者均以男性多见;UC患者平均诊断年龄高于CD患者,两组IBD患者均未见明显年龄双高峰;CD和UC以城市患者多见,且均缺乏家族聚集性特征。更多还原

【Abstract】 Background: Inflammatory bowel disease(IBD) is a group of chronic relapsing inflammatory intestinal disease with unknown etiology,comprising Crohn’s disease(CD) and ulcerative colitis(UC).The incidence of IBD is increasing in China year by year.Aims: To retrospectively analyze the demographic data of IBD patients.Methods: Demographic data including gender,age,residence and familial aggregation of 766 IBD in-patients from July 2002 to June 2011 at Shanghai Ruijin Hospital were retrospectively analyzed.Results: The incidence of IBD was increased during the past 9 years.The ratio of male to female in CD and UC was 2.02∶ 1 and 1.36∶ 1,respectively.The average onset age was significantly lower in CD than in UC [(33.30 ± 14.76) years vs.(40.10 ± 17.55) years,P < 0.0001].The peak age of CD was younger than UC.The patients with IBD from urban area were more common than from rural area.1.14% of CD and 1.68% of UC had family history.Conclusions: The incidence of IBD is increased during the past 9 years.The crescendo increase of CD incidence is greater than that of UC.The ratio of male to female in IBD patients shows a male predominance.The average age of UC is elder than CD,and there is no bimodal age distribution.The IBD patients from urban area are more common,and familial aggregation is not obvious.更多还原