【摘要】 目的探讨抗结核治疗病史对乙型重型肝炎临床特点及预后的影响。方法通过对比有抗结核治疗病史的乙型重型肝炎85例患者与无抗结核病史的乙型重型肝炎123例患者,了解抗结核治疗病史对乙型重型肝炎的影响。结果与无抗结核病史的乙型重型肝炎比较,有抗结核治疗病史的乙型重型肝炎死亡率高(P=0.0062),住院天数延长(P=0.04),并发症(脾大、腹水、肝硬化、自发性腹膜炎)发生频率较高(P<0.05);凝血酶原时间、凝血酶原活动度、白蛋白、总胆红素、肌酐与无抗结核治疗病史的乙型重型肝炎比较差异有统计学意义(P<0.05)。结论抗结核治疗病史可以显著影响乙型重型肝炎的临床表现及预后。更多还原

【Abstract】 Objective To investigate the effect of anti-tuberculosis history on clinical characteristics and prognosis of severe hepatitis B. Methods The clinical characteristics and prognosis of severe hepatitis B were compared between 85 patients with anti-tuberculosis treatment and 123 patients without anti-tuberculosis history. Results Severe hepatitis B with anti-tuberculosis history had a significantly high death rate( P = 0. 0062),prolonged hospitalization( P = 0. 04),and high incidence of complications( splenomegaly,peritonitis,ascites and cirrhosis)( P < 0. 05) compared with severe hepatitis B without anti-tuberculosis history. Prothrombin time,prothrombin activity,albumin,total bilirubin,and creatinine were statistically more serious in severe hepatitis B with anti-tuberculosis history( P < 0. 05). Conclusion Severe hepatitis B with anti-tuberculosis history has a worse clinical characteristics and a poorer prognosis.更多还原