【摘要】 通过活性追踪分离从千斤拔(Flemingia philippinensis Merr.et Rolfe.)干燥根中分离到9个化合物,通过现代波谱学方法鉴定化学结构分别为Eriosematin(1);Flemichapparin C(2);咖啡酸三十烷酯(3);Flemiphilippinin A(4);大黄素甲醚(5);染料木黄酮(6);Osajin(7);3,5-二羟基肉桂酸二十八酯(8);Lupinalbin A(9),化合物3和8为千斤拔属中首次分离鉴定。体外抗肿瘤活性研究结果表明,黄酮类化合物1、4、6、7和9对MCF-7、Hela、HepG2、B16细胞均具有较强的增殖抑制活性,可能是千斤拔的主要抗肿瘤活性成分。更多还原

【Abstract】 Bioassay-directed fractionation of the Flemingia philippinensis Merr. et Rolfe led to isolation of compounds by modern chromatography. Nine compounds were isolated and identified as Eriosematin( 1),Flemichapparin C( 2),3’,4’-Dihydroxy-trans-cinamic acid myricyl ester( 3),Flemiphilippinin A( 4),Physcion( 10),Genistein( 6),Osajin( 7),octacosyl-3,5-dihydroxy-cinnamate( 8),Lupinalbin A( 9). Compounds 3 and 8 were isolated and identificated from the Flemingia genus for the first time. And their anti-tumor activities were evaluated. Results demonstrated that flavonoids compounds 1,4,6,7 and 9 exhibit significant anti-proliferative activity towards some well established cancer cell lines,e. g. MCF-7,Hela,HepG2 and B16,which showed these flavonoids compounds may be the main anti-cancer compounds of Flemingia philippinensis Merr. et Rolfe.更多还原