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竹节参总皂苷抑制急性低压缺氧大鼠脑和心肌损伤的形态学观察

The Morphological Observation of Panax japonicus Total Saponins Inhibit Acute Hypobaric Hypoxia Injury on Rats’ Brain and Myocardial

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【作者】 周湘洁牛东滨郭志刚王亮赵琦杜学礼窦跃龙

【Author】 ZHOU Xiang-jie1,NIU Dong-bin2,GUO Zhi-gang3,WANG Liang2,ZHAO Qi2,DU Xue-li1,DOU Yue-long1 1 Clinical Center of Beijing Space City,Logistic of General Armament Headquaters of PLA;2 China Astronaut Research and Training Center,Beijing 100094;3 Department of Chemical Engineering,Tsinghua University Beijing 100084

【机构】 中国人民解放军总装备部后勤部航天城门诊部中国航天员科研训练中心清华大学化工系

【摘要】 在模拟海拔8000米高空的急性低压缺氧条件下,研究了竹节参总皂苷对Wistar大鼠的脑、心肌组织和细胞损伤的预防效果。实验结果表明未给药的阴性对照组Wistar大鼠的脑和心肌组织以及细胞均遭到了严重损伤。而竹节参总皂苷和红景天提取物给药组的Wistar大鼠,其脑和心肌组织以及细胞的损伤程度明显减轻。其中竹节参总皂苷给药组的效果最明显。

【Abstract】 In the simulated conditions of acute hypobaric hypoxia altitude of 8000 meters,the effective prevention of Panax japonicus total saponins(PJTS) to Wistar rats’ brain,myocardial tissues and cell damage were investigated.The experimental results showed that the negative control group which was out of treatment,cerebral,myocardial tissues and cells of Wistar rats suffered serious injury;while the Wistar rats group with Panax japonicus total saponins and Rhodiola rosea extracts treated,their brain,myocardial tissue and cell’s damage had significantly reduced.The group with best effect was treated by Panax japonicus total saponin.

  • 【文献出处】 天然产物研究与开发 ,Natural Product Research and Development , 编辑部邮箱 ,2013年02期
  • 【分类号】R285.5
  • 【被引频次】3
  • 【下载频次】156
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