ObjectiveTo investigate the protective effects and mechanisms of rosiglitazone on lung injury in severe acute pancreatitis(SAP).MethodsSeventy-two SD rats were randomized into three groups: sham operation(SO) group,SAP group and rosiglitazone-pretreated group. The model of SAP was induced by retrograde injection of 5% sodium tauro cholate into the bili-pancreatic duct in SD rats. Rats of rosiglitazone-pretreated group were given 10 mg/kg rosiglitazone in traperitoneally 30 min before inducing SAP. The amyla...