【摘要】 目的探讨Toll样受体7,8(Toll like receptor 7,8,TLR7,8)在非小细胞肺癌中的表达及其与非小细胞肺癌临床病理特征之间的关系,为进一步研究TLR在肺癌治疗中的应用提供理论依据。方法采用免疫组化SP法检测43例非小细胞肺癌组织和20例癌旁正常肺组织中TLR7、TLR8蛋白的表达水平,分析TLR7、TLR8的表达与非小细胞肺癌临床病理特征之间的关系。结果①TLR7主要在核周表达,TLR8在细胞质中表达,呈弥散表达。②TLR7在43例非小细胞肺癌阳性表达率为48.8%,高于癌旁正常肺组织的15.0%(P<0.05);TLR8在43例非小细胞肺癌组织阳性表达率为69.8%,高于癌旁正常肺组织的20.0%(P<0.05)。③TLR7表达与年龄、吸烟、肺癌淋巴结转移、TNM分期、分化程度无相关性,与性别、病理类型有关。TLR8表达与吸烟有关。TLR7表达和TLR8表达无相关性。结论 TLR7、TLR8在非小细胞肺癌组织中的表达均高于正常肺组织。TLR7、TLR 8可能参与了肺癌的发病机制,更多还原

【Abstract】 Objective To investigate the expressions of Toll like receptor 7(TLR7)and Toll like receptor 8(TLR8)in non-small cell lung cancer(NSCLC)and their relationship with clinicopathologic characteristics of NSCLC.Methods The protein expressions of TLR7 and TLR8 were immunohistochemically detected in samples of 43 NSCLC tissues and 20 normal lung tissues.The relationship between the expressions and the clinicopathologic characteristics of NSCLC was analyzed.Results TLR7 was predominantly expressed in perinuclear areas,while TLR8 expression was in a cytoplasmical diffuse pattern.The expressions of TLR7and TLR8 in 43 cases of NSCLC tissues were significantly higher than those in 20 cases of normal lung tissues(48.8% vs.15.0% for TLR7,69.8% vs.20.0% for TLR8,P<0.05).The expression of TLR7 was not related to smoking,age,gender,differentiation,TNM stage,lymph node metastasis,but with gender and histology.The expression of TLR8 was only correlated with smoking.There was no correlation between the expressions of TLR7 and TLR8.Conclusion TLR7 and TLR8 were intensely expressed in NSCLC tissues,which suggested that TLR7 and TLR8 may be implicated in the pathogenesis of NSCLC.更多还原