【摘要】 目的:探讨抗核糖体P蛋白抗体和系统性红斑狼疮(SLE)狼疮性肾炎(LN)、抗核糖体P蛋白抗体与LN病理分型的关系。方法:收集行肾活检的60例SLE患者临床资料,分析抗核糖体P蛋白抗体与LN的关系及与LN病理分型的关系。结果:(1)抗核糖体P蛋白抗体与LN(临床指标)存在关系(OR=3.48,P<0.05),抗核糖体P蛋白抗体与抗Ds-DNA抗体协同时也与LN相关(P<0.05)。(2)抗核糖体P蛋白抗体阳性组与抗核糖体P蛋白抗体阴性组相比较,Ⅴ型LN在抗核糖体P蛋白抗体阳性组有更高的发生频率(分别为75.0%和32.5%),差别具有统计学意义(χ2=4.25,P<0.05)。结论:抗核糖体P蛋白抗体和活动性LN可能具有一定的联系,且抗核糖体P蛋白抗体与Ⅴ型LN也存在一定联系,此结论对临床医生判断是否有LN活动及可能的LN病理类型具有一定的指导意义。更多还原

【Abstract】 Objective: To study the associations between antibodies to ribosomal P proteins and lupus nephritis(LN)clinically,especially the associations between antibodies to ribosomal P proteins and histopathologic patterns of lupus nephritis.Methods: Sixty patients of systemic lupus erythematosus(SLE) with biopsy of kidney were selected.At the same time,the materials associated with patients were collected and the associations between antibodies to ribosomal P proteins and lupus nephritis,especially the associations between antibodies to ribosomal P proteins and pathology of lupus nephritis were analyzed.Results: Firstly: antibodies to ribosomal P proteins were associated with lupus nephritis(clinically)(OR:3.48,P<0.05).Secondly: Compared patients of SLE with anti-ribosomal P proteins anti-bodies and those without anti-ribosomal P proteins antibodies,the patients with anti-ribosomal bodies had a higher frequency of class Ⅴ lupus nephritis(75.0% vs 32.5%,Chi Square:4.25,P<0.05).Conclusion: There may be associations between antibodies to ribosomal P proteins and active lupus nephritis,especially the associations between antibodies to ribosomal P proteins and class Ⅴ lupus nephritis,which may contribute to recognizing the active lupus nephritis and class Ⅴ lupus nephritis clinically.更多还原