【摘要】 在酸性条件下,溴化钠对NaIO4-H2O2-甲氧氯普胺弱化学发光具有增敏作用,结合流动注射技术建立了一种测定甲氧氯普胺的新方法。在优化实验条件下,相对化学发光强度与甲氧氯普胺的质量浓度在1.00×10-9～1.20×10-6g/mL范围内呈良好的线性关系,检出限为3.5×10-10g/mL,相对标准偏差(ρ=1.00×10-7g/mL,n=11)为2.5%。该方法已成功用于片剂及加标尿样中甲氧氯普胺含量的测定,回收率为96%～100%,与标准方法相对照,测定结果基本一致。更多还原

【Abstract】 In this paper,based on the obvious enhancing effect of sodium bromide on the NaIO4-H2O2-metoclopramide weak chemiluminescence(CL) reaction system under acidic conditions and combined with the flow injection analysis,a new method for the determination of metoclopramide was proposed.Under the optimum conditions,the relative CL intensities were proportional to the metoclopramide concentrations in the range of 1.00×10-9-1.20×10-6 g/mL with a detection limit of 3.5×10-10 g/mL.The relative standard deviation(ρ=1.00×10-7g/mL,n=11) was 2.5%.The proposed method was successfully applied in the determination of metoclopramide tablets and spiked urine sample with recoveries of 96%-100%.The results were in agreement with that of the standard method更多还原