【摘要】 目的通过分析卵巢低反应患者应用两种促排卵方案的治疗结局,探讨卵巢低反应患者体外受精(IVF)助孕的理想方案。方法回顾性分析2011年11月至2012年10月我中心低反应患者行超短方案促排卵治疗215周期。微刺激方案69周期,比较其人绒毛膜促性腺激素(HCG)日黄体生成素(LH)值、获卵数,移植日子宫内膜厚度、周期取消率,受精率、优胚率及妊娠率。结果超短方案获卵数显著高于微刺激方案(4.92±3.49 vs 2.46±2.69,P<0.001),子宫内膜厚度显著高于微刺激方案(10.05±1.98 vs 8.62±2.42,P<0.001),周期取消率显著低于微刺激方案(19.07%vs 68.12%,P<0.001),妊娠率、正常受精率、优胚率、种植率均无显著差异。结论与微刺激方案相比,超短方案可减少卵巢低反应患者取卵次数,降低周期取消率,总体也未增加患者经济负担,是卵巢低反应患者更易接受的一种简便有效促排卵方案。更多还原

【Abstract】 Objective:To explore a better protocol for the poor ovarian responders undergoing IVF/ICSI by analyzing the outcomes of the patients treated with two different controlled ovarian hyperstimulation(COH) protocols in IVF/ICSI.Methods:The retrospective analysis involved 215 cycles with ultra-short term protocol and 69 cycles with mild stimulation protocol in Maternal and Child Care Hospital of Shaanxi Province from November2011 to October 2012.The LH levels on the HCG day,oocytes retrieved,thickness of endometrial in transplantation day,cycle cancellation rate,fertilization rate,top-quality embryo rate and pregnancy rate were analyzed to assess which protocol is the optimal for these patients.Results;The oocytes retrieved in ultra-short term protocol group were significantly more than those in mild stimulation protocol(4.92±3.49 vs.2.46 ± 2.69,P < 0.001).The endometrial thickness in transplantation day in ultra-short term protocol was significantly thicker than that of mild stimulus protocol[(10.05 ± 1.98) mm vs.(8.62 ± 2.42) mm,P < 0.001)].The cycle cancellation rate was significantly lower than that of mild stimulus protocol(19.07%vs.68.12%,P<0.001).However the pregnancy rate,the normal fertilization rate,superior embryo rate and planting rate were not significantly different between the two groups.Conclusions:Compared with mild stimulates protocol,ultra-short GnRH-agonist protocol can decrease the times of oocytes retrieval operation in patients with poor ovarian response and reduce cycle cancellation rate,and does not increase the patients economic burden.Therefore,the patients with poor ovarian response are more likely to accept a simple project to stimulate ovulation.更多还原