【摘要】 目的 探讨脂质体多肽复合物联合Th1细胞的抗肿瘤活性及机制。方法 建立荷黑色素小鼠模型,实验分为对照组、Th1+多肽治疗组、Th1+脂质体多肽治疗组以及Th1+OVA治疗组。观察各组别对肿瘤体积、宿主生存及淋巴细胞活化能力的影响。结果 与对照组及Th1+多肽治疗组相比,Th1+脂质体多肽治疗组可显著抑制肿瘤的生长,延长荷瘤小鼠生存时间,并通过活化肿瘤特异性细胞毒性T细胞提高抗肿瘤活性。结论 Th1联合脂质体多肽复合物免疫疗法可有效诱导荷瘤机体产生有效的抗肿瘤活性。更多还原

【Abstract】 Objecive The present study aims to assess the anti- tumor effects of combined treatment with liposome- peptides with Th1 cells and to investigate the possible involved mechanism.Methods B16 OVA melanoma tumor- bearing mice model was established.The mice were divided into the control group,Thl + peptides group,Thl + liposome- peptides group and Thl + OVA group.The changes in tumor volume,survival of recipients and activities of immune cells were analyzed.Results We found that tumor growth was significantly inhibited and survival rale was significantly improved by the treatment with Thl + liposome- peptides as compared with contol group and Thl + peptides group.Tumor eradication was crucially dependent on the generation of tumor- specific CTLs in the tumor DLNs and tumor site.Conclusion These results identify that Thl combined with liposome- peptides is a novel approach In induce anti- tumor immune effectively.更多还原