【摘要】 目的:探讨NF-κB及PTEN在子宫内膜异位症中的表达及其意义。方法:采用免疫组化技术SP法检测异位内膜组(40例),在位内膜组(40例)及正常内膜组(30例)中NF-κB及PTEN蛋白的表达水平。结果:NF-κB在三组内膜中表达强弱依次为异位内膜>在位内膜>正常内膜,其差异有显著统计学意义(P<0.01);PTEN在三组内膜中表达强弱依次为异位内膜<在位内膜<正常内膜,其差异有显著统计学意义(P<0.01)。结论:NF-κB和PTEN可能与子宫内膜异位症发生发展密切相关。更多还原

【Abstract】 Objective To explore the expressions and significance of NF-κB and PTEN in endometriosis. Methods The expressions of NF-κB and PTEN were detected by immunohistochemical SP method in 40 cases of ectopic endometrium, 40 cases of eutopic endometrium, and 30 cases of normal endometrium. Results The expressions of NF-κB was the highest in ectopic endometrium , followed by eutopic endometrium , and was the lowest in normal endometrium ( P < 0 . 01 ) . While the expressions of PTEN was the lowest in ectopic endometrium, followed by eutopic endometrium, and was the highest in normal endometrium (P < 0.01). Conclusion The expressions of NF-κB and PTEN were positively associated with the development and progress of endometriosis.更多还原