【摘要】 目的:探讨夫妻双方均感染乙型肝炎病毒(HBV)对IVF/ICSI治疗中胚胎发育及妊娠结局的影响。方法:实验组为夫妇双方均乙肝表面抗原(HBsAg)阳性,对照组为夫妇双方均乙肝表面抗原(HBsAg)阴性。比较两组的正常受精率、卵裂率、优质胚胎率、着床率及临床妊娠率有无差异。结果:除优质胚胎率(58.61%比60.96%;P>0.05)外,HBV感染组正常受精率(77.11%比84.61%;P<0.05)、卵裂率(86.00%比98.23%;P<0.05)、着床率(11.11%比28.19%;P<0.05)及临床妊娠率(14.71%比37.25%;P<0.05)均较无HBV感染组显著降低,差异有统计学意义。结论:夫妻双方均为HBV感染者可能干扰了胚胎的发育,最终影响妊娠结局。更多还原

【Abstract】 Objective To investigate the effects of hepatitis B virus(HBV) infection in couples on the fetal growth and pregnancy outcomes of assisted reproductive technology.Methods 34 infertile couples,with positive hepatitis B surface antigen(HBsAg),receiving IVF /ICSI-ET,were included as infection group.And 102 infertile couples,with negative HBsAg,receiving IVF /ICSI-ET were included as control group.The normal fertilization rate,cleavage rate,rate of good quality embryos,implantation rate,and clinical pregnancy rate were recorded and compared between the two groups.Results Except for high-grade embryo rate(58.61% vs.60.96%,P > 0.05),the normal fertilization rate,cleavage rate,implantation rate and clinical pregnancy rate in infection group were significantly lower than those in control group(77.11% vs.84.61,86.00% vs.98.23%,11.11% vs.28.19%,14.71% vs.37.25%,all P < 0.05).Conclusion HBV infection in couples could affect the outcomes of in vitro fertilization and embryo transfer treatment.更多还原