【摘要】 目的:探讨甲状腺功能亢进症(甲亢)对青春期甲亢患者骨龄及骨代谢的影响。方法:检测60例青春期甲亢患者及50例健康受试者的血清游离甲状腺激素、生长激素(GH)、碱性磷酸酶(ALP)、骨钙素(BPG)及骨龄测定。结果:甲亢组骨龄明显落后于对照组,GH明显低于对照组,骨代谢指标高于对照组;甲亢组FT3与骨龄落后差值呈正相关,与GH呈负相关;甲亢病程≤1年组骨龄落后差值及ALP均明显低于病程>1年组,GH高于病程>1年组。结论:青春期甲亢患者骨龄发育落后;FT3与骨龄落后关系更为密切;甲亢病程越长,骨龄落后程度越明显;骨代谢增高及GH减少可能是引起骨龄落后的重要因素。更多还原

【Abstract】 Objective To characterize the bone metabolism and bone age (BA) of adolescent patients with hyperthyroidism. Methods Serum free T3 (FT3), free T4, growth hormone, alkaline phosphatase, osteocalcin and BA in 60 adolescent patients with hyperthyroidism (hyperthyroidism group) and 50 healthy controls (control group) were detected. Results Compared to those in control group, BA was significantly backward, level of GH was lower, and bone metabolic markers were higher in hyperthyroid group. In hyperthyroid group, level of FT3 was positively correlated with BA backward, and was negatively correlated with GH level. As compared to those in patients with hyperthyroidism more than 1 year, BA backward difference and ALP level were significantly lower and GH level was higher in patients with hyperthyroidism less than 1 year. Conclusion BA of adolescent patients with hyperthyroidism was lagged. FT3 and BA backwark were more closely correlated. The longer the duration of hyperthyroidism, the more obvious BA backward was. The increased bone metabolism and GH reduction may be the important factors in causing BA backward.更多还原