【摘要】 目的探讨采用体线圈行前列腺3.0T磁共振波谱(MRS)检查的可行性,总结3D1H-MRS在正常前列腺中的表现。方法收集20名中老年健康志愿者行3.0T MRI常规检查、扩散加权成像及MRS检查。年龄为41～80岁,平均年龄(56±11)岁。MRS以体线圈为信号接收线圈,用Proseme序列进行扫描,体素分为正常外腺区、正常内腺区。然后工作软件自动计算每个体素的胆碱(Cho)相对值、(胆碱+肌酸)/枸橼酸盐[(Cho+Cr)/Cit]的比值。正常前列腺内、外腺分为左、右两侧,每侧由上到下分为底部、中部和尖部3部分,这样每个志愿者测量12个感兴趣区,每个感兴趣区包括0～3个可用体素平均计算。结果20名健康志愿者获得体素201个,其中可用体素170个(84.6%),不可用体素为31个(15.4%)。20名中老年健康志愿者前列腺外腺区的(Cho+Cr)/Cit平均值是0.39±0.21,内腺区的(Cho+Cr)/Cit平均值是0.50±0.17,2组间比较差异有统计学意义(t=3.219,P<0.01)。结论①用3.0T体线圈可以顺利完成对前列腺的MRS检查,并可以获得用于分析的体素,其在临床实践中具有可行性。②中老年正常前列腺内腺和外腺的代谢物含量是不同的,差异有统计学意义(t=3.219,P<0.01),内腺区(Cho+Cr)/Cit平均值高于外腺区,进一步对其病变进行MRS定量研究时应根据解剖进行分区研究。更多还原

【Abstract】 Objective To discuss the clinical feasibility of proton magnetic resonance(MR) spectroscopy of the prostate with body coil at 3T,and to summarize1H-MRS performance of normal prostate in Chinese adults.Methods Twenty elderly healthy volunteers(age range:41~80 years;mean age:(56±11) years underwent 3.0T MR imaging,the diffusion-weighted imaging(DWI) and MRS imaging with body coils for signal reception.MR spectroscopy was performed with proseme sequence.Voxels were classifed into healthy peripheral zone,central gland.The relative value of choline and the choline plus creatine-to-citrate(Cho+Cr/Cit) ratio were calculated for all voxels.The right and left side of the peripheral and central zone were divided into bottom,middle and tip regions of interesting(ROI).Totally 12 ROIs were obtained from each normal case,0~3 voxels of each ROI were used in the analysis.Results In all voxels obtained from 20 elderly healthy volunteers,the numbers of available voxels were 170(84.6%),the numbers of inavailable voxels were 31(15.4%).Mean Cho+Cr/Cit ratios for healthy tissues were 0.39 ±0.21(standard deviation) for peripheral zone,0.50±0.17 for central gland;they were statistically different(t=3.219,P<0.01).Conclusion ① MRS of the prostate with body coil at 3T can be successfully performed,and can obtain available voxels for the analysis,so it is feasible in the clinical practice.②The metabolites levels of the peripheral and central zone in the prostate of middle and aged male healthy volunteers are statistically different(t=3.219,P<0.01),so further quantitative analysis of prostate lesions by MRS should be performed according to anatomical partitio.更多还原