【摘要】 目的观察小剂量静脉滴注甲基强的松龙联合吸入高剂量布地奈德对儿童哮喘急性发作的治疗效果。方法将46例哮喘急性发作患儿随机分为试验组和观察组各23例,其中观察组给予静滴地塞米松,2次/d,雾化吸沙丁胺醇,3次/d。试验组给予甲基强的松龙静滴,1次/8 h;雾化吸沙丁胺醇和布地奈德,3次/d,观察两组临床疗效及不良反应。结果经过比较发现治疗后7 d试验组PEFam;PEFpm;FEV1;FEV1/FVC(%)改善情况治疗组明显优于观察组,差异有统计学意义(P<0.05),并且日间哮喘症状评分,夜间哮喘症状评分、明显低于对照组,治疗后7 d和14 d试验组临床计分改善情况明显优于对照组,差异有统计学意义(P<0.05),两组均未见明显的不良反应。结论小剂量甲基强的松龙联合高剂量雾化吸入布地奈德治疗儿童哮喘急性发作,疗效显著,值得在临床推广。更多还原

【Abstract】 Objective To evaluate the effect of nebulized budesonide(BUD) and small doses intravenous drip methylprednisolone on acute exacerbations of asthma in children.Methods Forty six children with asthma were randomly divided into experimental group and observation group with 23 cases in each group,the observation group was given intravenous dexamethasone,2 times/day,atomizing inhalation of salbutamol,3 times/day.The experimental group was given methylprednisolone intravenous drip,1 time/8 h;atomizing inhalation salbutamol and budesonide,3 times/day.The clinical effect and adverse reaction of two groups were observed.Results After the treatment of 7 days,the improvement of PEFam,PEFpm,FEV1 and FEV1/FVC(%) in the experimental group was better than the observation group,the difference was statistically significant(P<0.05).The asthma symptoms score(daytime and nighttime) in the experimental group was significantly lower than the control group.After the treatment of 7 days and 14 days,the clinical score in the experimental group was significantly higher than those in the control group,the difference was statistically significant(P<0.05).There was no adverse reaction in both groups.Conclusion The low dose methylprednisolone combined with high dose nebulized budesonide is effective in the treatment of acute attack of asthma in children,and can be widely used in clinic.更多还原