【摘要】 目的探讨慢性乙型肝炎患者血清中IL-8和IL-23分泌水平的变化及其之间的相互关联,以期为乙型肝炎的诊断及临床治疗监控提供参考。方法选取经检查确诊的43例乙型肝炎患者作为研究对象,应用双抗体夹心酶联免疫吸附法(ELISA)定量检测患者血清中IL-8和IL-23的分泌水平,并以36名正常健康人血清作比较。结果慢性乙型肝炎患者血清中IL-8和IL-23的浓度分别为(96.4±51.6)μg/L和(140.5±50.1)pg/ml,均高于正常健康人血清中IL-8[(81.2±29.2)μg/L]和IL-23[(47.1±8.5)pg/ml]的浓度(P<0.01),并且血清中IL-8和IL-23的表达水平呈明显的正相关(P<0.01)。结论慢性乙型肝炎患者血清中IL-8和IL-23水平显著升高,其可能与慢性乙型肝炎的发病和病理损伤密切相关,检测血清中IL-8和IL-23的分泌水平为乙型肝炎的诊断和治疗监控提供了一个有应用价值的临床指标。更多还原

【Abstract】 Objective To explore the clinical significance of the changes of Interleukin-8(IL-8) and interleukin-23(IL-23) in patients with chronic hepatitis B in hopes of providing basis for the diagnosis and treatment of hepatitis B.Methods A total of 43 patients diagnosed as chronic type B hepatitis were selected for the research objects.The serum level of IL-8 and IL-23 were detected with sandwich-ELISA.Sera from 36 volunteers were set as control.Results The levels of IL-8 and IL-23 in the research objects were(96.4±51.6)μg/L and(140.5±50.1)pg/ml,respectively,which were significantly higher than those [(81.2±29.2)μg/L and(47.1±8.5)pg/ml,respectively] in the controls(P<0.01).The expression of IL-8 and IL-23 showed a strong positive correlation.Conclusion The increased levels of IL-8 and IL-23 might be closely related with the pathogeny and pathological injury of chronic hepatitis B.To monitor their levels can direct the diagnosis and treatment of chronic hepatitis B.更多还原