【摘要】 目的探讨血清同型半胱氨酸(HCY)水平与脑梗死之间的关系。方法检测140例脑梗死患者血清HCY、叶酸(FA)、维生素B12(VitB12)及血脂等指标,并与80例健康对照者相比较。结果脑梗死组血清HCY及甘油三脂(TG)水平高于健康对照组[(16.67±9.06)μmol/L vs.(10.51±2.33)μmol/L,和(1.63±1.12)mmol/L vs.(1.34±0.43)mmol/L,P均<0.001],而FA及VitB12水平则低于健康对照组[(4.62±2.37)g/L vs.(8.47±1.56)g/L,和(255.32±83.43)ng/L vs.(334.6±53.88)ng/L,P值均<0.001],两对照组间总胆固醇(TCHO)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)比较差异没有统计学意义(P>0.05)。结论血清HCY升高可能是脑梗死的危险因素,导致HCY升高的原因可能与血清内叶酸和维生素B12的降低有关。更多还原

【Abstract】 Objective To explore the relationship between serum homocysteine and cerebral infarction.Methods Serum HCY,folic acid(FA),vitamin B12 and cholesterol and other indicators of 140 patients with cerebral infarction were detected and compared with 80 healthy controls.Results Serum levels of HCY and triglyceride(TG) in infarction group were higher than those of healthy control group [(16.67 ± 9.06) μmol/L vs(10.51 ±2.33) μmol/L,and(1.63 ±1.12) mmol/L vs(1.34 ±0.43) mmol/L,all P values were <0.001],while serum levels of FA and VitB12 were lower than those of healthy control group [(4.62 ± 2.37) g/L vs(8.47 ± 1.56) g/L,and(255.32 ± 83.43) ng/L vs(334.6 ± 53.88) ng/L,all P values were < 0.001].There was no significant difference between these two groups in total cholesterol(TC),high density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C)(P > 0.05).Conclusion Elevated serum level of HCY may be another risk factor for cerebral infarction,and elevated serum level of HCY may be associated with lower serum levels of FA and VitB12.更多还原