【摘要】 目的探讨艾司西酞普兰和帕罗西汀治疗抑郁症的疗效及安全性。方法将76例抑郁症患者随机分为艾司西酞普兰组(38例,10～20 mg/d)和帕罗西汀组(38例,20～40 mg/d),疗程各8周。分别采用汉密尔顿抑郁量表17项、临床整体量表-疗效总评估量表评定疗效,不良反应症状量表评定不良反应。结果两组疗效相当(P>0.05),但艾司西酞普兰组起效更快,不良反应更少(P<0.05)。结论艾司西酞普兰是一种理想的抗抑郁药。更多还原

【Abstract】 Objective To explore the efficacy and safety of escitalopram and paroxetine in treatment of patients with depression.Methods Seventy six patients with depression were randomly assigned into 2 groups: 38 cases in escitalopram group were treated with 10 ～ 20 mg / d and 38 cases in paroxetine group treated with 20 ～ 40 mg / d,the treatment course in each group was 8 weeks.HAMD17 and CGI-SI were applied for evaluation of efficacy,and TESS was applied for evaluation of adverse events.Results Escitalopram and paroxetine have similar therapeutic efficacy(P > 0.05),and escitalopram has faster action than that of paroxetine(P < 0.05).The incidence of adverse events in patients of escitalopram group is less than that of patients in paroxetine group(P < 0.05).Conclusion Escitalopram is an ideal antidepressant.更多还原