【摘要】 目的探讨脉压指数(PPI)与老年高血压患者血胱抑素C(CysC)和尿微量蛋白的关系,为早期防治老年高血压肾损害提供临床依据。方法将139例老年高血压患者根据PPI分为3组:A组(46例)PPI<0.40、B组(49例)PPI0.40～0.55、C组(44例)PPI>0.55;全部患者检测血清尿素氮、肌酐、CysC、尿微量蛋白等。结果 C组血CysC、尿微量白蛋白(mAlb)、尿IgG、尿NAG酶、尿α1-微球蛋白(α1-MG)指标与A组比较,均有显著性差异(P<0.01)。C组与B组比较,尿mAlb、尿NAG酶、尿IgG和尿α1-MG的排泄增加(P<0.05或P<0.01)。B组与A组比较,尿mAlb、尿IgG和尿α1-MG的排泄增加(P<0.01)。PPI与老年高血压患者的血CysC、尿微量蛋白水平呈正相关(P<0.05)。结论老年高血压患者的早期肾脏损害与PPI有关,PPI是老年高血压患者早期肾脏损害的重要危险因素。更多还原

【Abstract】 Objective To investigate the relationship of pulse pressure index(PPI) with serum cystatin C(CysC) and urine trace protein in elderly hypertensive patients,in order to provide clinical evidence for early prevention and treatment of elderly patients with hypertensive kidney damage.Methods 139 cases of elderly hypertensive patients were divided into 3 groups according to PPI:group A(46 cases) with a PPI<0.40,group B(49 cases) with a PPI 0.40-0.55,group C(44 cases)with a PPI>0.55.Serum urea nitrogen,creatinine,cystatin C,urine trace protein were detected in all patients.Results There were significant differences in the levels of blood CysC,urine mAlb,urine IgG,urine NAG enzyme and urine α1-MG betweent group C and group A(P<0.01).Compared with group B,the excretion of urine mAlb and NAG enzyme,the levels of urine IgG and urine α1-MG of group C were increased significantly(P<0.05 or P<0.01).Compared with group A,the excretion of urine mAlb,the levels of urine IgG and urine α1-MG of group B were increased significantly(P<0.01).There was positive correlation of PPI with the levels of blood CysC,urine trace protein in elderly hypertensive patients(P<0.05).Conclusions Early kidney damage in elderly hypertensive patients is related to PPI.PPI is an important risk factor for early kidney damage in elderly hypertensive patients.更多还原