【摘要】 目的:探讨间质化疗联合手术治疗口腔鳞癌的疗效。方法:自1998-01～2008-11对149例口腔鳞癌患者进行间质化疗联合手术(77例)及常规化疗联合手术(72例),观察2组的复发率、转移率、不良反应及近期生存率等。结果:间质化疗联合手术组与常规化疗联合手术组相比术后复发率、原发灶大小变化、生存率均较大、不良反应发生率、手术后淋巴转移率均较小,有明显差异(P<0.05)。手术前淋巴结转移率无明显差异(P>0.05)。结论:间质化疗联合手术治疗口腔鳞癌效果优于常规化疗联合手术。更多还原

【Abstract】 Objective: To study the effects of interstitial chemotherapy combined with surgery(ICS) in the treatment of oral squamous cell carcinoma(OSCC).Methods: 149 patients with OSCC were treated by ICS(ICS group,N=77) and conventional chemotherapy combined with surgery(CCS group,N=72) respectively.2-year-follow-up was conducted.The recurrence rate,lymph node metastasis rate,adverse reaction,recent survival rate in the 2 groups were compared.Results: The recurrence rate,incidence rate of the adverse reaction,and postoperative lymph node metastasis were lower(P<0.05),the tumor size decrease and survival rate were higher in ICS group than those in CCS group(P<0.05).Preoperative lymph node metastasis were not significantly different(P>0.05).Conclusion: Interstitial chemotherapy combined with surgery is more effective than conventional chemotherapy combined with surgery in the treatment of OSCC.更多还原