【摘要】 目的 探讨不同类型及程度肺功能损害的特发性肺纤维化(idiopat hic pulmonary fibrosis,IPF)薄层MSCT表现特征及与肺功能检查诸项指标之间的相关性。方法 经临床病理证实的30例IPF患者均行薄层MSCT扫描,观察不同类型及程度IPF的薄层MSCT征象,并对其预定层面各征象累及范围进行评分。将薄层MSCT各征象与肺功能诸项指标进行Spearman相关性分析。结果 30例IPF均表现为不同程度限制性通气功能障碍及弥散功能障碍。薄层MSCT各征象总半定量评分与肺活量(vital capacity,VC;r=-0.646,P<0.001)、肺总量(total lung capacity,TLC;r=-0.661,P<0.001)、残气量(residual volume,RV;r=-0.415,P=0.023)呈负相关;与用力肺活量(forced inspiratory vital capacity,FVC;r=-0.624,P<0.001)、第1秒用力呼气容积(forced expiratory volume in one second,FEV1;r=-0.483,P=0.007)呈负相关;与一氧化碳弥散量(diffusion capacity for carbon monoxide of the lung,DLCO;r=-0.732,P<0.001)、比弥散量(specific diffusing capacity,DLCO/VA;r=-0.504,P=0.005)呈负相关;与限制性通气功能障碍分级(r=0.843,P<0.001)、弥散功能障碍分级(r=0.838,P<0.001)呈正相关。结论不同类型及程度肺功能损害患者薄层MSCT表现不同,薄层MSCT半定量评分能够很好反映肺功能损害的状况。更多还原

【Abstract】 Objective To determine the correlation between thin-section MSCT findings and pulmonary function test results different styls and various extemt pulmonary function defect patients with idiopathic pulmonary fibrosis.Methods 30 cases of idiopathic pulmonary fibrosis proved clinically and/or pathologically were presented.All patients underwent thin-section MSCT.Thinsection MSCT scans were assessed for the presence and the extent of abnormal parenchyma in different styls and various extemt pulmonary function defect patients.The correlation between thin-section MSCT score and the values of pulmonary function tests was examined by using the Spearman rank correlation coefficient.Results Of 30 cases,the pulmonary function tests of all patients revealed various exent restrictive ventilatory and diffuse function defect.The analytic results showed the total scores in thin-section CT negatively correlated with vital capacity(VC,r=-0.646,P<0.001),total lung capacity(TLC,r=-0.661,P<0.001),residual volume(RV,r=-0.415,P=0.023),forced inspiratory vital capacity(FVC,r=-0.624,P<0.001),forced expiratory volume in one second(FEV1,r=-0.483,P=0.007),diffusion capacity for carbon monoxide of the lung(DLCO,r=-0.732,P<0.001),specific diffusing capacity(DLCO/VA,r=-0.504,P=0.005),positively correlated with the staging of ventilatory defect(r=0.843,P<0.001) and diffuse function defect(r=0.838,P<0.001).Conclusion There are different MSCT heterophanies in different styles and various extent pulmonary function defect of idiopathic pulmonary fibrosis,and there is good correlation between the scorning system and different styles and various extent pulmonary functiong defect.更多还原