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高龄五指山小型猪近交系血液生化指标测定

Blood Biochemical Tests of Senior Inbred Wuzhishan Miniature Pigs

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【作者】 黄雷牟玉莲杨述林王辰程玉柱徐盼冯书堂

【Author】 HUANG Lei;MU Yu-lian;YANG Shu-lin;WANG Chen;CHENG Yu-zhu;XU Pan;FENG Shu-tang;Institute of Animal Sciences,Chinese Academy of Agricultural Sciences;

【机构】 中国农业科学院北京畜牧兽医研究所

【摘要】 目的了解猪龄和性别对五指山小型猪(WZSP)近交系血液生化指标的影响。方法 WZSP近交系F17、F186月龄青年猪34头(7♂,27♀),5—6高龄猪21头(8♂,13♀),禁食12 h后经由前腔静脉采血,用全自动生化分析仪检测血液生化指标。结果青年猪和高龄猪有部分血液生化指标具有性别差异(P<0.05),其中青年猪有3项高龄猪有7项;青年猪和高龄猪有16项血清生化指标具有差异(P<0.05)。结论 WZSP近交系血液生化指标有着明显的年龄差异,这对选用高龄猪作为人类老年化动物模型提供了基础参考数据。

【Abstract】 Objective To analysis the blood biochemical parameters influenced by age and gender of inbreed Wuzhishan miniature pigs.Method 34 6-month-old pigs(7 ♂,27 ♀),as well as 21 pigs of 5—6 years old(8♂,13♀) from F17,F18offsprings of inbred WZSP were selected.After 12 hours of fasting,blood was collected via the superior vena cava and biochemical indexes were analyzed by full-Automatic biochemical analyzer.Result In all the blood biochemical indexes,3 of them showed gender differences(P < 0.05) between young pigs,while 7 of them showed gender differences(P < 0.05) among aged pigs.Meanwhile 16 of the blood biochemical indexes showed age differences(P < 0.05).Conclusion The blood biochemical indexes of WZSP inbred lines display a significant age difference(P < 0.05).This provides a basic reference data for choosing the aged miniature pigs as human aging animal models.

【基金】 国家科技支撑(No.2012BAI3904);国家重点基础研究发展计划(973计划)(No.2011CB944202)
  • 【文献出处】 实验动物科学 ,Laboratory Animal Science , 编辑部邮箱 ,2013年05期
  • 【分类号】R-332;S865.1
  • 【被引频次】4
  • 【下载频次】90
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