【摘要】 目的:对肺癌MSCT灌注成像及相关灌注参数进行分析,研究肺癌MSCT灌注成像与病理类型之间的关系,探讨其临床应用价值。方法:对32例肺癌患者,先行常规CT扫描,确定肿瘤的中心层面,然后采用电影技术对肿瘤中心层面进行连续扫描,以获得该层面内组织的时间-密度曲线,计算出血流量(BF)、血容量(BV)、平均通过时间(MTT)、表面渗透性(PS),以此评价肿瘤灌注情况,并与病理分型进行对比分析。结果:中心型肺癌与周围性肺癌各灌注参数均无明显差异(P>0.05)。对各型肺癌的灌注参数进行分析得出:各型肺癌BF、PS值大小关系为鳞癌<腺癌(P<0.05),鳞癌<小细胞癌(P<0.05),腺癌BF、PS值小于小细胞癌但两者之间的差异无统计学意义(P>0.05);各型肺癌BV值大小顺序为鳞癌<腺癌<小细胞癌(P<0.05);各型肺癌MTT值之间无明显差异。结论:肺癌MSCT灌注成像反映各型肺癌血流特点及肿瘤内部微血管密度变化,有利于肺癌病理分型诊断。更多还原

【Abstract】 Objective:Analyzed MSCT perfusion imaging and each parameter,to study the relation between MSCT perfusion and pathological types.Methods:To define the largest scan through carrying on a regular CT scan,then continuous CT scan were performed in the largest scan of the thirty-two lesions by film scanning,to obtain time-density curve of this level tissue.To calculate blood flow(BF),blood volume(BV),meat transit time(MTT),and permeability surface(PS),MSCT perfusion parameters and evaluate perfusion condition,MSCT perfusion parameters and pathological types were analyzed.Results:Each perfusion parameter of centric and peripheral pulmonary carcinoma had no statistical difference(P>0.05).The mean values of BF,PS were as follow as in different type of lung cancer squamous cell carcinoma<adenocarcinoma<small cell carcinoma,but the BF,PS value of adenocarcinoma was less than small cell carcinoma,which had no statistical significance(P>0.05).The mean values of BV were squamous cell carcinoma<adenocarcinoma<adenocarcinoma carcinoma(P<0.05).The mean values of MTT of types of the lung cancer had no statistical difference(P>0.05).Conclusion:MSCT perfusion imaging of lung cancer can fully reflect the blood flow and micro-vascular density of lung cancer essentially and contribute to the pathological type of the lung cancer.更多还原