【摘要】 目的:原发性肝癌患者肝动脉化疗栓塞两次后,行三维适形放疗,以评估综合治疗原发性肝癌的疗效及毒副反应。方法:对120例不能手术的原发性肝癌随机分成化疗栓塞联合三维适放疗组(A组61例)和单纯动脉化疗栓塞组(B组59例)。所有患者均行肝动脉化疗栓塞二次,A组组患者随后行三维适形放疗,照射25-30次,每次2GY,总剂量50-60GY。结果:A组和B组1-、2-、3-年生存率分别为75.4%、62.3%、44.3%和55.9%、30.5%、15.3%。两者有显著性差异。A组和B组的有效率分别为86.9%、55.9%,两者有统计学差异。结论:三维适形放疗联合肝动脉化疗栓塞治疗不能手术的原发性肝癌不失为一种有效的治疗方法,延长了患者生存期,而没有增加毒副反应。更多还原

【Abstract】 Objective:To explore the effect of three dimensional conformal radiation(3DCRT) combined with transarterial chemoembolization for unresectable primary hepatic cancer(PHC).Mothods:All 120 patients with unresectable primary hepatic cancer were randomized into 2 groups:3DCRT combined with TACE(group A 61 patients) and TACE alone(group B 59 patients).TACE were performed with 2 cycles.In group A,61patients received a dose of 50-60Gy at 2Gy per fraction,5 times a week.Results:The 1-,2-,3-year survival rates were 75.4%,62.3% and 44.3% in group A and 55.9%,30.5% and 15.3% in group B.The difference between the two groups was significant.The response rates were 86.9% in group A,and 55.9% in group B.The difference was statistically significant.The incidence and severity of side effects did not differ significantly between the two groups.Conclusion:Three conformal radiation therapy combined with transarterial chemoembolizaton is effective for unresectable primary hepatic cancer and can prolong the survival time without increasing toxicities.更多还原