【摘要】 目的:探讨原发性胃恶性淋巴瘤(primary gastric malignant lymphoma,PGL)的临床特点、诊断与治疗及其预后。方法:回顾性分析4年半内收治的24例PGL患者的临床资料。结果:临床表现以上腹痛、消化道出血、纳差、消瘦多见。病变主要位于胃窦和胃体,术后病理类型均为非霍奇金淋巴瘤,其中B淋巴细胞型11例,T淋巴细胞型3例,BT双淋巴细胞型1例,未分型9例。ⅠE期9例(37.5%),ⅡE期7例(29.2%),ⅢE期6例(25.0%),ⅣE期2例(8.3%)。4例HP感染者术后给予抗HP治疗。在获得最终随访的21例中有13例存活超过5年。结论:PGL根据临床症状、内镜下特点及活检多能确诊。肿瘤病理类型、临床分期、是否存在合并症和HP感染是影响预后的重要因素。手术治疗有助于提高远期生存率,改善预后。更多还原

【Abstract】 Objective:To investigate the clinical characteristics,diagnosis,treatment and prognostic of primary gastric malignant lymphoma.Methods: The clinical data of 24 patients with PGL treated in our hospital was analyzed retrospectively.Results: The main clinical manifestations were epigastric pain,gastrointestinal bleeding,poor appetite,emaciation.Endoscopically,ulceration,diffused infiltration,nodular could be observed.The lesions were located mainly in the antrum and body of stomach.All patients underwent surgical treatment,19 cases with subtotal gastrectomy(B-I/B-II),5 cases total gastrectomy.All cases were diagnosed as non-Hodgkin’s lymphoma pathologically,of them 11 were B lymphocyte,3 were T lymphocyte,1 was BT lymphocyte,9 were non classification.ⅠE stage 9 cases(37.5%),ⅡE stage 7 cases(29.2%),ⅢE stage 6 cases(25.0%),ⅣE stage 2 cases(8.3%).4 cases of HP infection treatment to anti-HP.The prognosis was correlated with histological type and clinical staging.13 cases survived more than 5 years.Conclusion: PGL can be confirmed according to clinical symptoms,endoscopic features,and biopsies.Histological type,clinical stage,the existence of complications and H.pylori infection are important factors affecting the prognosis.Surgical treatment can improve the long-term survival and improve prognosis.更多还原