【摘要】 目的 探讨同型半胱氨酸(Hcy)与原发性高血压的关系。方法 选择经实验室、X线、心电图、超声心动图等确诊的原发性高血压患者97例,并进一步经冠状动脉造影术和头颅MRI或CT分为3组:单纯原发性高血压组(43例)、原发性高血压伴冠心病组(22例)和原发性高血压并发缺血性脑卒中组(32例),健康查体者60例作为对照组。均采用7170A全自动生化分析仪进行Hcy检测,结果 进行统计学分析。结果 血清Hcy水平,原发性高血压伴冠心病组(21.3±8.1μmol/L)和原发性高血压伴缺血性脑卒中组(23.6±7.3μmol/L)均较单纯原发性高血压组(17.3±6.2μmol/L)为高,差异有统计学显著性意义(t=3.16,P<0.05);三者与正常对照组(9.3±3.8μmol/L)比较差异均有统计学非常显著性意义(t=6.36,6.98和7.12,P均<0.01);且Hcy男性高于女性(P<0.05)。结论 原发性高血压患者血清Hcy水平升高;当并发冠心病或缺血性脑卒中时,血清Hcy水平则更高,同时具有性别差异。更多还原

【Abstract】 Objective To explore the relationship of homocysteine(Hcy) with the essential hypertension.Methods Chose 97 cases of patients with essential hypertension(EH) that made a definite diagnosis with laboratory,X-ray,electrocardiogram, echocardiography,and further by coronary angiography and head MRI or CT,they was divided into three groups:pure essential hypertension group(n=43),primary hypertension associated with coronary heart disease group(n=22) and primary hypertension with cerebral ischemic stroke group(n=32).60 cases of healthy physical examination was as a control group. Detected serum Hcy with Hitachi 7170A Automatic Biochemical Analyzer and the results were statistically analyzed.Results Serum Hcy levels,primary hypertension associated with coronary heart disease group(21.3 ±8.1 μmol/L) and primary hypertension with ischemic cerebral infarction group(23.6±7.3 μmol/L) were higher than a simple essential hypertension group(17.3±6.2 μmol/L),with significant difference(t=3.16,P<0.05).Three groups compared with the normal control group(9.3±3.8 μmol/L) had very significant difference(t=6.36,6.98,7.12,P<0.01),and Hcy in men than women(P <0.05).Conclusion There were elevated Hcy in serum of essential hypertension patients,with amalgamative coronary heart disease(CHD) or ischemic stroke,serum Hcy levels were higher,and had sex differences at the same time.更多还原