【摘要】 为明确含铜4.5%的317L不锈钢的体外抗菌性能及其生物相容性,通过制备分布着4.5%的ε-Cu相的317L不锈钢(317L-Cu),应用体外细胞直接接触实验检测317L-Cu材料表面成骨细胞的生长形态及增殖,并评价体外317L-Cu材料的抗菌性能。结果表明,317L-Cu材料在体外具有很好的抗菌性能,可以有效杀灭材料表面大肠杆菌;317L-Cu材料与成骨细胞直接接触培养48h,材料表面的成骨细胞生长良好,细胞增殖活性与钛合金材料比较无显著性差异。因此,317L-Cu具有良好的细胞相容性,有望成为具有抗菌性新型医用生物材料。更多还原

【Abstract】 To study the in vitro antibacterial activity and biocompatibility of 317L stainless steel containing 4.5% copper alloy(317L-Cu),we produced 317L-Cu stainless steel withε-Cu phase.The cell proliferation of osteoblasts on material surface was detected in vitro.Escherichia coli was cultured with 317L-Cu for evaluating the antibacterial activity.We found that the 317L-Cu could effectively kill the Escherichia coli on material surface.The cell proliferation of osteoblasts on material surface was not different significantly,compared with titanium material.Our study clearly demonstrated that the 317L-Cu alloys had a significant antimicrobial activity and was biocompatible in vitro,so it would be suitable to be used as a new medical material with antibacterial activity.更多还原