【摘要】 目的:探讨血管内皮细胞生长因子(vascular endothelial cell growth factor,VEGF)基因-2578 C/A单核苷酸多态性位点与中国北方地区银屑病易感性的相关性。方法:随机收集2005年10月至2007年5月在哈尔滨医科大学附属一、二院皮肤科门诊就诊的246例寻常型银屑病患者(实验组)和271名正常对照个体(对照组)的外周静脉血,使用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法分析VEGF-2578 C/A多态位点基因型,并进行统计学分析。结果:在实验组中,VEGF-2578 C/A等位基因频率分别为74.80%、25.20%;在正常对照组中,VEGF-2578 C/A等位基因频率分别为76.59%、23.41%,两组VEGF-2578 C/A多态位点基因型的分布差异无统计学意义(P>0.05)。结论:VEGF基因-2578 C/A的多态性与中国北方汉族人群银屑病的易感性无明显相关性。更多还原

【Abstract】 Objective: To investigate the relationship between vascular endothelial growth factor(VEGF) polymorphisms and psoriasis in north of China.Methods: DNA genotyping was performed on peripheral blood leukocytes in 246 patients of psoriasis and 271 controls.One common polymorphism(2578) of VEGF gene was analyzed by PCR-RFLP.Results: In patients,the allele frequencies of the 2578 were as follows: C,74.80%;T,25.20%.In controls,the allele frequencies of 2578 were 76.59% and 23.41%,no significant difference of the genotype frequencies and allele frequencies in the polymorphic site was observed between the two groups.Conclusion: VEGF gene-2578 C/A polymorphism was probably not associated with the psoriasis susceptibility.更多还原