【摘要】 目的:探讨α-、β-雌激素受体(α、β-ER)、孕激素受体(PR)在腺性膀胱炎中的蛋白和mRNA表达水平及其临床意义。方法:采用免疫组化SP和实时荧光PCR法检测腺性膀胱炎(57例)和正常膀胱(15例)黏膜组织中α、β-ER、PR的表达。结果:α-ER在腺性膀胱炎的膀胱三角区及膀胱底部中的蛋白与mRNA的表达均明显低于正常对照,而β-ER、PR在2个部位的表达均与正常对照无统计学意义。结论:α-ER的表达下调可能参与了腺性膀胱炎的病理形成。更多还原

【Abstract】 Objectives:To investigate the expression and significance of α-,β-strogen receptor(α-,β-ER)and progestogen receptor(PR)in cystitis glandularis. Methods:The expression of α-,β-ER and PR was detected by immunohistochemical and quantitative PCR technique in 57 cases of cystitis glandularis and 15 cases of normal bladder. Results:The expression rate ofα-ER was significantly higher than that of normal bladder mucosa tissue. The expression rate of β-ER and PR had no difference between two groups of trigone zone and bladder fundus. Conclusion:The down-regulation expression of α-ER in bladder mucosa tissue may be related to the biological behavior of cystitis glandularis.更多还原