Objective:To investigate the protective effect and anti -oxidative activity mechanism of Grifola frondosa in serum,heart and liver of aged mice. Methods:The aging mice were established with D-galactose by intraperitoneal injection. Grifola frondosa was administrated to mice by gavage 100%(Grifola frondosa large dose),50% (Grifola frondosa small dose. After six weeks,the mice were executed. The serum,heart and liver tissue of mice were collected. The content of malondialdehyde(MDA),activity of superoxide dis...