【摘要】 缬沙坦是临床常用的抗高血压药物,除降压外其对心血管重构的作用也逐渐引起人们的重视.降钙素基因相关肽(calcitonin gene related peptide,CGRP)是目前已知的最强舒血管物质,也参与了心血管重构的过程.以缬沙坦治疗自发性高血压大鼠(spontaneously hypertensive rats,SHR)8周,能明显降低SHR血压,抑制心肌肥厚,改善心室重构,同时也显著抑制胸主动脉和肠系膜上动脉血管重构.缬沙坦治疗还显著升高SHR大鼠血浆CGRP浓度,上调背根神经节和肠系膜上动脉中CGRP表达.结果提示,缬沙坦降低SHR大鼠血压,改善心血管重构,其作用可能与提高CGRP水平有关.更多还原

【Abstract】 Valsartan is a commonly used antihypertensive drug in clinic. Besides the effect on blood pressure(BP) regulation, the impact of valsartan on cardiovascular remodeling also gradually attracts people’s attention. Calcitonin gene related peptide(CGRP) is one of the most powerful vasodilatation factors, which is also involved in the process of cardiovascular remodeling. 8 weeks treatment of valsartan significantly reduced BP, inhibited myocardial hypertrophy and improved ventricular remodeling in spontaneously hypertensive rats(SHR). It also inhibited the vascular remodeling in thoracic aorta and superior mesenteric artery. Meanwhile, valsartan treatment significantly elevated plasma CGRP concentration, increased CGRP expression in dorsal root ganglia and superior mesenteric artery of SHR. These results suggest that elevated CGRP level may involve in BP and cardiovascular remodeling regulation by valsartan.更多还原