【摘要】 目的:考察对乙酰氨基酚合成工艺的条件,反应条件涉及温度、物料比、反应时间、及反应溶剂等各条件对反应收率的影响。方法:通过正交设计寻找最佳工艺,运用熔点测定仪、元素分析、IR等手段进行确认。结果:棉酚与磺胺衍生物合成的最佳工艺为反应温度45℃,反应时间为1h,反应溶剂为无水乙醇,物料比为1:2.5。结论:生成的衍生物有较强的脂溶性,在优化工艺下进行反应产量较高,为乙酰氨基酚衍生物合成提供了较好的方法。更多还原

【Abstract】 Objective:In this paper,a method of studying paracetamol synthesis technology of conditions,reaction conditions concerned with reaction temperation,ratio of reactants,reaction time and sort of solvent.Methods:by orthogonal experimental design search for best process,use melting point apparatus,UV,IR,determination measure whether have the new material.By TLC monitor the extent of reactions.Results:paracetamol synthesis technology of best condition is reaction temperation 45℃,reaction time 1h,sort of solvent is anhydrous,and alcohol ratio of reactants 1:2.5.Conclusion:these derivatives have strong fatsoluble,by orthogonal experimental design search for best process have high yield,and provide a good method of studying p-acetaminophenol synthesis.更多还原