The present study was to investigate the role of the quinolinic acid(QUIN) and its relationship with N-methyl-D-aspartic acid(NMDA) receptor and metabotropic glutamate receptor 1(mGluR1) in depression induced by chronic unpredictable mild stress(CUMS) in hippocampus.CUMS-induced depression model was established in Sprague-Dawley rats.Intrahippocampal injections of QUIN,QUIN antagonist Ro61-8048,non-competitive NMDA receptor antagonist MK-801 and mGluR1 antagonist AIDA were respectively adopted by rat brain ...
【基金】
supported by the Fundamental Research Funds for the Central University of China(No.GK200901011)