【摘要】 目的 研究裸鼹鼠(NMR)的生化位点特征，初步建立裸鼹鼠生化位点的检测方法。方法 以小鼠近交系的生化位点为参照，应用小鼠的检测方法，检测裸鼹鼠的11种同工酶的活性。结果 裸鼹鼠的酯酶-1、转铁蛋白为慢带;葡萄糖磷酸异构酶-1、苹果酸酶-1、异柠檬酸脱氢酶-1为中间带;血红蛋白β链、肽酶-3、碱性磷酸酶-1、磷酸葡萄糖变位酶-1、酯酶-3、过氧化氢酶-2为快带。结论 7只裸鼹鼠的11个生化位点为一致的条带，无多态性，表现为纯合型。更多还原

【Abstract】 Objective A elementary detection method on biochemical marker loci was established to study the characteristics of naked mole rat biochemical loci. Methods With inbred mouse as a reference,11 isozymes of naked mole rat were detected according to the methods for biochemical markers of mice.Results The esterase-1, transferrin of naked mole rat showed slower bands; glucose phosphate isomerase-1, malic enzyme-1, isocitrate dehydrogenase-1 showed intermediate bands; hemoglobin βchain, peptidase-3, alkaline phosphatase-1, phosphate glucose mutase-1, esterase-3, hydrogen peroxide enzyme-2 showed faster bands. Conclusion Biochemical locis of 7 naked mole rat performed consistent bands, showed homozygous, no polymorphism.更多还原