【摘要】 目的 评估高脂喂养胰岛素抵抗大鼠甲状腺的功能状态。方法 采用高脂饲料喂养建立胰岛素抵抗大鼠模型，以大鼠清醒状态下正常血糖-高血浆胰岛素钳夹试验进行评估，留取血样后测定大鼠血清甲状腺功能指标和血脂指标。结果 (1)与正常饮食组(NC组)比较，高脂饮食组(HF组)60～120 min的平均葡萄糖输注率(GIR60～120)明显降低（P <0.05）,TC、TG、LDL-C、FFA水平明显升高，HDL-C水平明显降低，差异均具有统计学意义（P <0.05）。(2)与NC组比较，HF组大鼠血清TSH、FT3、FT4，差异均无统计学意义(P>0.05)。但HF组大鼠血清TSH水平与TG水平呈正相关(R=0.749,P<0.05),与HDL-C水平呈负相关(R=-0.172,P<0.05)，与TC、LDL-C、FFA水平无相关关系(P>0.05)。结论 高脂喂养胰岛素抵抗大鼠的甲状腺功能较正常组大鼠无明显变化，但血清TSH水平与血脂水平密切相关。更多还原

【Abstract】 Objective To assess the thyroid function on the high-fat insulin resistant rats.Methods Insulin resistant rats were induced by high-fat diet feeding,then assessed by euglycemichyperinsulinemia clamp technique. Determine the index of thyroid function and serum lipid. Results(1) The glucose infusion rate(GIR60～120) was significantly decreased in HF group,(P<0.05). The level of serum TC、TG、LDL-C、FFA were significantly increased while HDL-C was decreased in high-fat diet(HF group), P<0.05.(2) The differences of TSHL?FT3and FT4between the NC and HF group were not statistically significant(P>0.05). The serum level of TSH has a positive correlation with TG(R=0.749,P<0.05) and has a negative correlation with HDL-C(R =-0.172, P<0.05). There were uncorrelation between TSH and TC, LDL-C, FFA. Conclusion The thyroid function of the high-fat diet insulin resistant rats was no significant differences with the normal rats,but the serum TSH was close to the serum level of lipid.更多还原