【摘要】 目的:探讨卵巢交界性上皮性肿瘤(BOT)的临床情况及影响复发的有关因素。方法:回顾性分析我院诊治的58例BOT患者的临床资料及治疗结局。结果:58例患者的平均发病年龄为37.6岁;临床表现以无症状的盆腔肿块为主,共29例占50.00%;血清肿瘤标志物:CA125升高33例(56.90%),CA199升高20例(34.48%),两者比较差异有统计学意义(P<0.05)。所有患者均进行手术治疗,其中37例患者行保留生育功能手术。分期以Ⅰ期最多,占87.93%;浆液性和黏液性分别为25例和33例。术后随访8～68月,患者均存活;4例(6.90%)复发,肿瘤有微乳头或浸润性种植的患者复发率较高(P<0.05)。5例保留生育功能手术的患者在手术后正常妊娠并分娩。结论:BOT患者较年轻,以Ⅰ期为主,血CA125检测对诊断有帮助。手术是主要治疗手段,患者预后较好。其复发与肿瘤存在微乳头或浸润性种植可能有关。对其进行保留生育功能手术是安全有效的,术后需长期随访。更多还原

【Abstract】 Objective:To evaluate the clinical features of borderline ovarian tumors( BOT) and to develop the potential prognostic factors of BOT. Methods:The clinical data of 58 patients with BOTS who were diagnosed and treated in our hospital were retrospectively analyzed. Results:The mean age of BOT patients was37. 6 years. The main clinical feature of BOT is the symptomless pelvic cavity mass,which was found in 29 cases( 50. 00% of the cases). 33 cases( 56. 90%) had a raised blood CA125level,and 20 cases( 34. 48%) raised in blood CA199level( P<0. 05). All patients underwent surgery as the initial treatment,of whom 37 cases underwent conservative surgery. Most of them were in FIGO stage Ⅰ( 87. 93%). Duration of follow-up was 8 ～ 68months. 4 cases( 6. 90%) developed a recurrence. The recurrence rate of micro-papillary carcinoma or micro-invasive carcinoma cases were higher than others( P<0. 05). Five patients underwent conservative surgery had normal spontaneous delivery after normal pregnancy. Conclusions:The clinical features of the borderline ovarian tumors is that most cases are young women,in FIGO stage Ⅰ. CA125can help to establish a diagnosis of BOT. Surgery is the main treatment of BOT,and patients have favorable prognosis after surgery.The recurrence of BOT may be related to micro-papillary carcinoma or micro-invasive carcinoma. Conservative surgery is proved an effective and safe treatment for borderline ovarian tumors,and long-term follow-up is required.更多还原