【摘要】 目的探讨核苷酸切除修复交叉互补基因(ERCC1)和人表皮生长因子(C-erbB2)在子宫内膜癌组织中的表达及其对化疗联合舒肝益肾方疗效的影响。方法将51例子宫内膜癌患者作为子宫内膜癌组,20例子宫内膜正常者为对照组。子宫内膜癌组给予化疗联合中药疏肝益肾方治疗。检测2组子宫内膜组织中ERCC1及C-erbB2表达,分析子宫内膜癌患者组织中C-erbB2、ERCC1表达对中西医结合治疗子宫内膜癌疗效的影响。结果 C-erbB2、ERCC1在子宫内膜癌组织中阳性表达随组织学分级增加而增强,G3级C-erbB2阳性率明显高于G1级和G2级(P<0.05);G3级的ERCC1阳性率明显高于G1级(P<0.05)。C-erbB2、ERCC1在子宫内膜癌组中阳性表达率明显高于对照组(P<0.05或P<0.01)。子宫内膜癌组C-erbB2、ERCC1阳性表达者的中西医结合疗效明显低于C-erbB2、ERCC1阴性表达者(P<0.05)。结论 ERCC1和C-erbB2表达状态有利于判断子宫内膜癌病理分级,并可用于疗效评估。更多还原

【Abstract】 Objective To investigate the expressions of nucleotide excision repair cross-complementing gene(ERCC1) and human epidermal growth factor(C-erbB2) in endometrial carcinoma tissue and their impact on the therapeutic effect of chemotherapy combined with liver-soothing kidney-tonifying formula.Methods Fifty-one patients with endometrial cancer and 20 subjects with normal endometrium were respectively as endometrial carcinoma group and control group.The former was treated with chemotherapy combined with liver-soothing kidney-tonifying formula.The expressions of ERCC1 and C-erbB2 in endometrial tissue of two groups were detected,and the impact of C-erbB2 and ERCC1 expressions on the therapeutic effect of integrated Chinese and Western medicine was analyzed.Results The positive expressions of C-erbB2 and ERCC1 in endometrial cancer tissue were increased with histological grading increasing.C-erbB2 positive rate at grade G 3 was significantly higher than at grades G 1 and G 2(P < 0.05),and ERCC1 positive rate at grade G 3 significantly higher than at grade G 1(P <0.05).Positive expression rates of C-erbB2 and ERCC1 in endometrial cancer group were significantly higher than in control group(P < 0.05 or P < 0.01).The therapeutic effect of integrated Chinese and Western medicine on patients with positive expressions of C-erbB2 and ERCC1 was significantly lower than that with negative ones(P < 0.05).Conclusion ERCC1 and C-erbB2 expressions are conducive to determining the pathological grading of endometrial carcinoma,and can be used to assess the therapeutic effect.更多还原