【摘要】 目的观察唐肌康和重组人表皮生长因子凝胶治疗糖尿病大鼠皮肤溃疡效果及差异性。方法同体对照,分别采用唐肌康和重组人表皮生长因子凝胶对10只糖尿病大鼠背部两侧皮肤溃疡进行外敷治疗,观察溃疡创面大小、自溶清创效果、有无换药疼痛。结果唐肌康自溶清创效果高于重组人表皮生长因子凝胶(t=-1.455,P=0.172);唐肌康换药疼痛显著低于重组人表皮生长因子凝胶(=68.850,P=0.000)。结论两种方法治疗糖尿病大鼠皮肤溃疡均有效,唐肌康自溶清创效果、换药疼痛优于重组人表皮生长因子凝胶。更多还原

【Abstract】 Objective To observe the effects and compare of the differences of Tangjikang ointment and recombinant human epidermal growth factor( rhEGF) gel treating skin ulcers in rats with diabetes. Method Diabetes was induced by peritoneal injection of streptozotocin and back skin ulcers were made by surgery method in 10 rats. Then the rats were topical administered with Tangjikang ointment( on the left side) and rhEGF Gel( on the right side) respectively,once a day until 14 days after beginning experiment. Size of ulcer,autolysis debridement effect and pain response were observed during wound healing. Results Tangjikang ointment was better than rhEGF for autolysis debridement( t =-1. 455,P = 0. 172); and more comfortable than rhEGF for medication pain( = 68. 850,P = 0. 000). Conclusion Two methods to treat skin ulcers in rats with diabetes were valid. Tangjikang ointment might better for autolysis debridement and medication pain than rhEGF gel.更多还原