【摘要】 目的观察重组人脑利钠肽(recombinant human brain natriuretic peptid,rhBNP)治疗慢性心力衰竭患者早期肾损害的临床效果。方法将慢性心力衰竭患者早期肾功能损害患者41例分为两组,治疗组21例,对照组20例,治疗组在常规治疗慢性心力衰竭的基础上给予rhBNP治疗,对照组给予常规治疗。观察两组间血尿素氮(BUN)、血清肌酐(Scr)、尿微量清蛋白(MA)、肾小球滤过率(GFR)变化。结果经治疗后两组间BUN、Scr无变化,两组中MA、GFR都有好转,但治疗组改善均优于对照组(P<0.05)。结论 rhBNP在治疗慢性心力衰竭患者早期肾功能损害中,能更有效改善肾功能,保护肾功能,延缓慢性心衰病程进展。更多还原

【Abstract】 Objective To observe the clinical effects of recombinant human brain natriuretic peptide in the treatment of chronic heart failure patients with early renal damage.Methods Chronic heart failure in patients with early renal dysfunction in 41 patients divided into two groups,20 cases of the treatment group,21 cases in the control group,the treatment group given rhBNP treatment on the basis of the conventional treatment of chronic heart failure,the control group received conventional therapy.Observed between the two groups of blood urea nitrogen(BUN),serum creatinine(Scr),urine micro albumin(MA),changes in the glomerular filtration rate(GFR).Results Between the two groups after treatment,BUN,Scr unchanged,two groups MA,GFR has improved,but the improvement in the treatment group than the control group(P<0.05).Conclusion rhBNP in treatment of chronic heart failure in patients with early renal dysfunction,can more effectively improve renal function and protect renal function and delay the progression of chronic heart failure.更多还原