【摘要】 目的探讨静脉预注右美托咪定对全麻下腹腔镜胆囊切除术患者围术期应激反应的影响。方法随机选取我院肝胆外科2010～2011年收治的腹腔镜胆囊切除术患者68例,均在全麻下进行手术,68例患者随机分为干预组和对照组各34例,干预组34例患者在麻醉诱导前静脉预注右美托咪定0.5μg/kg,对照组34例按体重给予等容量的生理盐水,观察两组患者围术期应激反应(苏醒拔管前、拔管时、拔管后2min、拔管后5min患者心率、血压、脉搏、血氧饱和度等指标变化)。结果干预组患者拔管前后血流动力学指标波动较小,明显优于对照组,差异有统计学意义(P<0.05),SpO2情况对比无统计学意义(P>0.05),对照组10例患者出现躁动,干预组2例。结论右美托咪定可抑制围术期应激反应,维持血流动力学稳定。更多还原

【Abstract】 Objective To investigate the effect of intravenous infusion of dexmedetomidine in laparoscopic cholecystectomy operation stress reaction in patients.Methods Laparoscopic cholecystectomy were randomly selected Department of Hepatobiliary Surgery of our hospital during 2010～2011 was performed in 68 cases,underwent operation under general anesthesia,68 patients were randomly divided into intervention group and control group with 34 cases in each group,the intervention group with 34 patients before induction of anesthesia,intravenous infusion of dexmedetomidine on 0.5μg/kg,normal saline control group 34 cases according to the weight given capacity,two group were observed in patients with stress reaction in operation period(before extubation,awake extubation,2 min after extubation,5 min after extubation in patients with heart rate,blood pressure,pluse,oxygen saturation changes).Results the patients in the intervention group before and after extubation hemodynamics fluctuation significantly better than the control group,the statistical difference is significant(P<0.05),SpO2 comparison is no statistical significance(P>0.05),control group 10 patients appeard agitated,intervention group of 2 cases.Conclusion dexmedetomidine can inhibit the stress reaction in operation period,maintain hemodynamic stability更多还原