【摘要】 目的探讨肺癌灌注参数和肿瘤微血管密度(microvessel density,MVD)相关性及对肺癌纵隔淋巴结转移倾向预测价值。方法我院手术后病理证实肺癌患者36例,将肺癌肿瘤各灌注参数血流量(blood flow,BF)、血容量(blood volume,BV)、平均通过时间(mean transit time,MTT)、表面通透性(permeability surface,PS)、肿块动脉强化峰值(peak height,PE)与肿瘤MVD计数行相关及回归分析,并比较纵隔淋巴结转移组患者与纵隔淋巴结无转移组患者各灌注参数及MVD计数之间差异,通过ROC法评价各肺癌灌注参数及MVD计数对肺癌患者纵隔淋巴结转移倾向的预测诊断价值。结果纵隔淋巴结有转移组患者肿瘤各灌注参数中肿瘤BF及MVD计数均较纵隔淋巴结无转移组患者升高。肿瘤BF、BV与肿瘤MVD计数呈正相关。结论肺癌灌注参数中血流量、血容量与肿瘤微血管密度计数存在线性相关性,且肿瘤血流量、血容量及肿瘤微血管密度可作为纵隔淋巴结转移倾向预测诊断因子。更多还原

【Abstract】 Objective To study the correlation between CT perfusion parameters with MVD and the predictive value of the perfusion parameters and MVD in mediastinal lymphatic node metastasis of lung cancer.Methods We analyzed 36 cases of lung cancer patients proved by pathology.The patients’ pathological slices were performed CD34 staining.All patients were divided into group with mediastinal lymphatic node metastasis and group without mediastinal lymphatic node metastasis.We compared the BV(blood volume),BF(blood flow),MTT(mean transit time),PS(permeability surface),PE(peak height)and MVD differences between two groups.Then we tried to correlate the CT perfusion parameters with the MVD counting,later we made a regression analysis to identified the concrete relation between the perfusion parameters and the MVD.Meanwhile we used ROC to analyze the value of the perfusion parameters and MVD in predicting mediastinal lymphatic node metastasis of lung cancer.Results BF and MVD counting is significantly different between the two groups.BF and BV are positive correlation with the MVD counting.Conclusion The CT perfusion parameters,such as BF and BV are positive correlation and linear dependence with the MVD.And the BF、BV and MVD counting are useful in predicting mediastinal lymphatic node metastasis of lung cancer.更多还原