【摘要】 目的探讨胱抑素C(cystatin C,Cys C)对2型糖尿病患者早期肾损害的评价意义。方法对2010年1月～2011年12月我院53例2型糖尿病患者按照MDRD公式计算出的eGFR进行分组,分别测定各组患者的血肌酐(Scr)、Cys C及尿微量白蛋白(mAlb),分析Cys C与Scr、mAlb的异常表达率以及与eGFR的相关性。结果 GFR正常组,mAlb的异常表达率为83.33%,而GFR轻度降低组mAlb和Cys C的异常表达率为66.67%和100%。结论在2型糖尿病患者中,CysC和mAlb比Scr更敏感地反映了肾小球滤过率的变化,mAlb敏感性最高,其次为Cys C,可以早期预测糖尿病肾脏损害的发生。更多还原

【Abstract】 Objective To explore the relationship of Cystatin C and the decrease of glomerular filtration rate in patients with type 2 diabetic mellitus.Methods The glomerular filtration rate of the 53 patients with type 2 diabetic mellitus was calculate by the MDRD formula.All the patients were from January 2010 to December 2011 in our hospital.Serum creatinine(Scr) and Cystatin C were measured in all patients.Then we analyzed the relationships between GFR and Cystatin C,Scr and Urine micro albumin(mAlb).Results The abnormal expression rate was 83.33% in patients with normal renal function,and were 66.67% and 100% in patients with mild decreasing of GFR.Conclusion Cys C and mAlb were more sensitive than Scr to predict the early damage of diabetic kidney disease.The mAlb was the most sensitive data to predict the damage of renal function,the second one was Cys C.更多还原