【摘要】 目的探讨补佳乐在冻融胚胎移植中的临床应用,寻找影响妊娠结局的可能因素。方法对南京妇幼保健院生殖医学中心2011年应用激素替代(补佳乐)方案进行冻融胚胎移植准备的316例患者资料进行回顾性分析,观察冻融胚胎移植结局的影响因素。结果补佳乐应用的各组年龄比较,大于13天组患者的年龄偏大(t=0.04,P<0.05);补佳乐应用时间显示,大于13天组、12~13天组、小于8天组患者的内膜厚度与平均内膜厚度相比均有差异(t值分别为0.45、0.37、0.58,均P<0.05);各组间妊娠率无明显差别(x~2=1.37,P>0.05);妊娠组与未妊娠组比较,在年龄、内膜厚度、补佳乐用药天数、补佳乐用量上均无明显差别(t值分别为0.89、0.21、0.38、0.25,均P>0.05)。结论应用补佳乐方案的冻融胚胎移植周期中,患者的年龄越大,应用补佳乐天数越长;应用补佳乐的天数及总量与内膜厚度及妊娠率并无显著性关系。更多还原

【Abstract】 Objective To investigate the clinical application of Progynova in frozen-thawed embryo transfer and to seek the possible factors influencing pregnancy outcomes.Methods Retrospective analysis was performed on data of 316 patients preparing for frozen-thawed embryo transfer with HRT(Progynova) in reproduction department of Nanjing Maternity and Child Health Hospital in 2011,aiming to observe the influencing factors of outcomes of frozen-thawed embryo transfer.Results The > 13 day group was older than other groups(t =0.04,P <0.05),and there were differences in endometrial thickness of > 13 day group,12-13 day group,and <8 day group in comparison with mean endometrial thickness(t value was 0.45,0.37 and 0.58,respectively,all P <0.05).There was no obvious difference in pregnancy rale among groups(x~2 = 1.37,P > 0.05).Compared with non-pregnant group,pregnant group was not significantly different in age,endometrial thickness,medication course and dose((value was 0.89,0.21,0.38 and 0.25,respectively,all P >0.05).Conclusion In frozen-thawed embryo transfer cycle,the older the patients,the longer the medication.The course and total amount of Progynova are not evidently correlated with the endometrial thickness and pregnancy rate.更多还原