【摘要】 目的探讨肾上腺素、布地奈德雾化吸入治疗气管插管患儿拔管后喉头水肿的疗效。方法回顾性分析124例重症肺炎行气管插管拔管后出现喉头水肿的患儿,根据拔管后主要治疗方法不同分为A组和B组,A组用氧气雾化吸入肾上腺素治疗喉头水肿,B组用氧气雾化吸入盐酸布地奈德治疗喉头水肿,观察两组喉头水肿症状持续时间、雾化后即刻动脉血气及雾化1h后呼吸频率和心率。结果 A组喉头水肿持续时间为(26.91±12.38)h,B组为(34.86±13.21)h,A组症状持续时间较B组短,两组比较,差异有统计学意义(t=-2.691,P<0.05);A组雾化后即刻动脉血氧分压为(88.57±9.06)mmHg,B组为(76.81±11.03)mmHg,A组动脉血氧分压较B组高,两组比较,差异有统计学意义(t=2.529,P<0.05);A组二氧化碳分压为(41.27±11.50)mmHg,B组为(62.21±11.31)mmHg,A组二氧化碳分压较B组低,两组比较,差异有统计学意义(t=-5.529,P<0.05);雾化1h后A组呼吸频率为(34.32±7.79)次/min,B组为(41.18±7.76)次/nin,A组呼吸频率较B组低,两组比较,差异有统计学意义(t=-3.899,P<0.05)。结论氧气雾化吸入肾上腺素可以缩短喉头水肿症状持续时间,提高动脉血氧分压,降低二氧化碳分压,降低呼吸频率。更多还原

【Abstract】 Objective To evaluate the efficacy of oxygen-driven aerosol inhalation of adrenaline and budesonide on children’ s laryngeal edema after removing endotracheal intubation.Methods This study was conducted by a retrospective analysis.Totally 124 children with laryngeal edema after removing endotracheal intubation were divided into group A and B according to different treatment methods.Group A was treated by using oxygen-driven aerosol inhalation of adrenaline,while group B was treated by using oxygen-driven aerosol inhalation of budesonide.Evaluation indicators were observed in two groups,including the duration of laryngeal edema,arterial blood gas immediately after finishing atomization inhalation,respiratory rate and heart rate lh after finishing atomization inhalation.Results The duration of laryngeal edema was 26.91 ± 12.38 h and 34.86 ± 13.21 h,respectively in group A and group B,and the difference was significant（t =-2.691,P <0.05）.The PaO₂ monitored immediately after finishing atomization inhalation was 88.57 ±9.06mmHg and 76.81 ± 11.03 mmllg,respectively in group A and group B,and the difference was still significant（t = 2.529,P < 0.05）.The PaCO₂ monitored immediately after finishing atomization inhalation in group A（41.27 ± 11.50 mmHg） was lower than that in group B（62.21 ±11.31 mmllg） with significant difference（t =-5.529,P <0.05）.The respiratory frequency was 34.32 ±7.79 in group A and 41.18 ±7.76 in group B.There was statistical significance in it（t =-3.899,P<0.05）.Conclusion Oxygen-driven aerosol inhalation of adrenaline can shorten the duration of laryngeal edema,improve PaO₂,reduce PaCO₂ and reduce respiratory frequency.更多还原