【摘要】 目的:探讨110例甲状腺乳头状癌(papillary thyroid carcinoma,PTC)、20例结节性甲状腺肿(nodular goiter,NG)和23例癌旁组织(precancerous tissue,PT)中RBP2表达与临床参数的关系。方法:免疫组化SP法测定2009-01-12-2012-03-20济宁医学院附属医院收集的NG、PTC和PT组织中RBP2分布的位置、表达及与临床参数的关系。结果:PTC、NG和PT组织中RBP2的阳性表达差异有统计学意义,χ2=-17.201,P<0.001。在PTC组织中RBP2的阳性表达率为52.7%,弱阳性表达率为36.2%;在NG组织中RBP2阳性表达率为30.0%,其中83.3%为弱阳性表达;与PT组织相比,RBP2的表达差异有统计学意义,U=-2.261,P=0.024。NG组织中RBP2的表达在年龄(U=-0.481,P=0.630)和性别(U=-0.825,P=0.409)方面差异均无统计学意义。PT组织RBP2弱阳性表达率为4.3%(1/23),RBP2的表达在年龄(U=-0.877,P=0.380)、性别(U=-0.594,P=0.552)、临床分期(U=-1.369,P=0.171)和淋巴结转移(U=-0.802,P=0.423)差异均无统计学意义。PTC组织与PT组织相比,两者差异有统计学意义,U=-4.149,P<0.001;与NG组织相比,两者差异有统计学意义,U=-2.085,P=0.037。PTC组织中无淋巴结转移组RBP2的阳性率与淋巴结转移组之间差异无统计学意义,U=-1.432,P=0.152;RBP2的表达在性别(U=-0.777,P=0.437)、临床分期(U=-1.726,P=0.084)和年龄(U=-1.236,P=0.216)之间差异无统计学意义。结论:RBP2是甲状腺肿瘤发生早期及恶性转化的重要标志,其表达的增加可以视作是判断甲状腺肿瘤发生的重要临床参考指标。更多还原

【Abstract】 OBJECTIVE:To investigate the prognostic significance of RBP2expression in patients with 110papillary thyroid carcinoma,20Nodular goiter and 23precancerous tissues.METHODS:From 2009-01-12to 2012-03-20in Affiliated Hospital of Jining Medical University the expressions of RBP2on surgically resected samples from nodular goiter,papillary thyroid carcinoma and precancerous tissue were detected by immunohistochemistry.RESULTS:RBP2 was localized mainly to the thyroid cell nucleus.There was significantly difference among the three groups(NG,PTC and PT)(χ2=-17.201,P<0.001).Immunohistochemical studies demonstrated that RBP2expression was higher in papillary thyroid carcinoma(52.7%)than that in nodular goiter(36.2%).Immunohistochemical studies demonstrated that RBP2expression was higher in nodular goiter(30.0%)than that in precancerous tissue(U=-2.261,P=0.024).There was no significantl association with age and gender(U=-0.481,P=0.630;U=-0.825,P=0.409)in precan cerous tissue.Only 1 case turned out to express RBP2protein from 23precancerous tissues.The expression of RBP2was not significantly associated with age,gender,clinical stage status,and lymph nodes metastasis(U=-0.877,P=0.380;U=-0.594,P= 0.552;U=-1.369,P=0.171;U =-0.802,P=0.423).Papillary thyroid carcinoma and precancerous tissue(U =-4.149,P<0.001).There was no difference between cases with positive lymph node metastases and cases with negative lymph nodes(U=-1.432,P=0.152).The expression of RBP2was not significantly associated with gender,stage status, and age(U=-0.777,P=0.437;U=-1.726,P=0.084;U=-1.236,P=0.216).CONCLUSIONS:RBP2is related well with the occurrence and malignant transformation of thyroid papillary carcinoma.The positive expression of RBP2can be used to estimate the potentiality and help for the adjuvant treatment.更多还原