【摘要】 目的:通过Meta分析系统评价p27Val109Gly基因多态性与肿瘤易感性的关系。方法:检索PubMed、Medline、Web of Science和中国知网等数据库中研究p27Val109Gly基因多态性与肿瘤易感性关系的研究。运用Rev-Man5.0软件进行异质性检验、系统性评价和分层亚组分析,计算合并OR及95%CI;应用State 11.0软件进行定量发表偏倚检验。结果:共纳入13项研究,累计病例组4 894例,对照组5 413例。G等位基因携带者肿瘤总体易感性降低,OR=0.81,95%CI=0.66～0.99,P=0.04,尤其是前列腺癌(OR=0.60,95%CI=0.36～0.98,P=0.04)和食管癌(OR=0.34,95%CI=0.22～0.55,P<0.01)。剔除不符合或不能进行HWE检验的研究后,再次行Meta分析。结果显示,G等位基因与肿瘤易感性无相关性,OR=0.82,95%CI=0.64～1.03,P=0.09。高加索人群(OR=0.97,95%CI=0.84～1.12,P=0.67)和亚洲人群(OR=0.77,95%CI=0.57～1.02,P=0.07)、基于医院(OR=0.70,95%CI=0.42～1.17,P=0.17)和社区(OR=0.86,95%CI=0.67～1.11,P=0.24)的肿瘤患者,p27Val109Gly基因多态性与肿瘤易感性无明显相关性。结论:p27Val109Gly基因多态性G等位基因与肿瘤的易感性呈负相关,尤其是前列腺癌和食管癌。这种相关性在高加索人、亚洲人及对照组来源于医院或社区的患者中不显著。更多还原

【Abstract】 OBJECTIVE:To investigate the association between p27Val109Gly polymorphism and cancer susceptibility.METHODS:We searched relevant articles from Pub med,Medline,Web of Science,CNKI database.We made systematicall and stratified evaluation by statistical analysis software Rev-Man5.0.We tested publication bias by State 11.0.RESULTS:Thirteen studies involving 4 894cases and 5 413controls were included.Total analysis found that G-allele could decrease susceptibility of all tumor(OR=0.81,95%CI=0.66-0.99,P=0.04),specially prostate cancer(OR=0.60,95%CI=0.36-0.98,P=0.04)and esophagus cancer(OR=0.34,95%CI=0.22-0.55,P<0.01).Re-analysis showed that there was no association(OR=0.82,95%CI=0.64-1.03,P=0.09)between the p27Val109Gly polymorphism and cancer risks.There was no association between Caucasian(OR=0.97,95%CI=0.84-1.12,P=0.67)and Asian(OR=0.77,95%CI=0.57-1.02,P=0.07)in hospital-based(OR=0.70,95%CI=0.42-1.17,P=0.17)and populationbased(OR=0.86,95%CI=0.67-1.11,P=0.24)patients.CONCLUSION:G-allele of p27Val109Gly polymorphism may be related with the cancer risk,especially prostate cancer and esophageal cancer as a low-risk factor.This relevance is not notable in Caucasians,Asians and patients from hospital.更多还原